Sleep

An FDA-approved migraine medication may hold the key to repairing broken circadian clocks. A computational screening study published this week in Molecular Diversity identifies dihydroergotamine (DHE) as a promising candidate for reversing the physiological damage caused by circadian disruption. In sleep-deprived mice, the drug restored weight stability, rescued recognition memory, and normalized sleep architecture through […]

CREB1 Emerges as Molecular Link Between Chronic Sleep Deprivation and Anxiety People who carry genetic variants that boost expression of the CREB1 gene face a 28 percent higher risk of developing anxiety, according to a new study that triangulates three independent lines of evidence. The finding, published in Progress in Neuro-Psychopharmacology & Biological Psychiatry, positions […]

In a large Swedish cohort with nearly two decades of follow-up, researchers found that the association between demanding or low-control jobs and dementia risk was substantially stronger among people who slept normally than among those with insomnia or short sleep. The findings suggest that poor sleep may obscure the long-term cognitive effects of job strain, […]

Combining high-dose caffeine with chronic sleep deprivation produces a synergistic impairment of male sexual performance and fertility in rats, driven by dysregulation of hypothalamic monoamine signaling and the stress-reproductive hormone axis, according to a study published July 8 in BMC Research Notes. Researchers at Afe Babalola University in Nigeria exposed adult male Long-Evans rats to […]

Researchers have created the first Per2LUC transgenic Syrian hamster, enabling real-time bioluminescence imaging of circadian clock function across multiple tissues, according to a study published in the Journal of Biological Rhythms. The Per2LUC model expresses a PER2::luciferase fusion protein, producing measurable bioluminescence rhythms that reflect the molecular state of the circadian clock in living tissue. […]

Exposure to broadband noise during NREM sleep suppresses the hippocampal sharp-wave ripples essential for memory consolidation, and the timing of the noise relative to these neural events determines the severity of the impairment, according to a study published July 8 in Current Biology. Researchers at the University of Michigan led by Karla Salgado-Puga, Utku Kaya […]

Targeted dream incubation (TDI) at sleep onset can influence dream content in subsequent REM sleep, according to a pilot study published June 24 in Frontiers in Sleep, suggesting that the hypnagogic period and REM sleep may share a continuous dream generation system. The study, led by Adam Haar Horowitz of MIT Media Lab and Beth […]

A new review published in Ageing Research Reviews synthesizes the evidence linking four modifiable lifestyle factors, nutrition, exercise, gut microbiota, and sleep, to brain health across the lifespan, offering a framework for delaying neurodegenerative disease through daily behavioral choices. Led by Andrew C. Shin of Texas Tech University, the review draws on original research and […]

Chronic caffeine treatment preserves memory, mood, and neuronal architecture in rats subjected to five weeks of REM sleep deprivation, according to a study published July 7 in Scientific Reports. Researchers at Ibn Tofail University in Morocco used the Modified Multiple Platform Method to induce REM sleep deprivation in rats for five weeks, then assessed the […]

Cardiorespiratory Sleep Staging Hits 70% Accuracy but Faces N1 Blind Spot and Validation Gap, Systematic Review Finds Date: 2026-07-08 Automatic sleep staging using only cardiorespiratory signals — derived from wearable sensors rather than full electroencephalography — achieves a practically meaningful accuracy of approximately 70%, but the field faces systematic shortcomings that limit clinical deployment, according […]