Sleep

Pharmacological and Behavioral Approaches to Narcolepsy: A Current Overview Researchers from Sechenov First Moscow State Medical University have published a concise overview of available treatments for narcolepsy, covering both pharmacological and behavioral strategies for managing the disorder’s two hallmark symptoms: excessive daytime sleepiness and cataplexy. Narcolepsy is a chronic neurological disorder affecting approximately 1 in […]

Sleep Disorders in Women: Why Sex-Specific Diagnosis and Treatment Matter A new review from researchers at Almazov National Medical Research Centre in St. Petersburg consolidates the evidence for sex-specific differences in sleep disorders, arguing that diagnostic and therapeutic approaches must account for the physiological changes women experience across their lifespan. Women are significantly more likely […]

“Brain Rot” After Heavy Screen Time Is a Sleep- and Circadian-Driven State, Not Neurodegeneration The colloquial term “brain rot” — used to describe the mental fog, attentional fragmentation, and cognitive fatigue that follows prolonged engagement with high-intensity digital media — is best understood as a sleep- and circadian-linked neurocognitive vulnerability state rather than a form […]

Sleep Instability Emerges as a Unifying Concept as AI and Wearables Reshape Sleep Diagnosis An editorial published in Frontiers in Sleep introduces sleep instability as a common thread across sleep disorders and argues that emerging technologies — artificial intelligence, wearable sensors, and advanced signal processing — are transforming how it can be measured and managed. […]

Sleep emerges as protective brain factor against urban living stress in new network mapping study A new study published in Neuroscience Bulletin introduces a novel brain mapping technique called exposure network mapping (ENM) to untangle how different environmental factors shape human brain networks. Among the factors examined, sleep stood out as a uniquely protective pattern, […]

Sleep regularity fails to improve after stroke, linked to depression and quality of life Stroke survivors have severely disrupted sleep-wake schedules that do not improve on their own after hospital discharge, according to a new longitudinal study published in the Journal of the American Heart Association. The irregularity is associated with higher depression scores and […]

Sleep Need Leaves a Molecular Signature at the Synapse A team led by Stephan Sigrist at Freie Universität Berlin has mapped the molecular landscape of sleep-driven synaptic remodeling with synapse-resolved proteomics and phosphoproteomics, revealing that elevated sleep pressure triggers a coordinated, compartment-specific shift toward dephosphorylation at the presynaptic terminal. The study, published in Proceedings of […]

Cleaning the sleeping brain: Can drugs restore the glymphatic system? A new review in Current Neuropharmacology maps out what goes wrong when the brain’s waste clearance system breaks down — and surveys the drugs that might fix it. The authors, led by Souvik Banerjee and colleagues from Chitkara University, India, argue that aquaporin-4 (AQP4) […]

How melatonin puts the brain to sleep — and what we still don’t know A review published in the Journal of Family Medicine and Primary Care lays out what decades of research have established about melatonin’s role in sleep — and where the evidence still falls short. Melatonin is a neurohormone produced by the […]

How a brainstem toxin model reveals the locus coeruleus’s role in sleep A systematic review of animal studies using the neurotoxin DSP4 finds that selectively destroying the brain’s primary noradrenaline source – the locus coeruleus – produces severe but inconsistent sleep disruptions, and identifies methodological factors that could explain […]